Generic Provigil and Nuvigil are both manufactured by the major pharmaceutical Cephalon and is approved by the Food and Drugs Administration (FDA) to cure narcolepsy and excessive sleeping. Along with the exposure of Nuvigil, people have been questioning the difference between the two drugs since both of them claim the same treatments and were produced by the same manufacturer. Read on to find out the truth behind two very similar medicines.

Provigil
Back in the eighties, the main active ingredient of generic Provigil which was modafinil, was first manufactured in a French Laboratory called Lafon with Professor Michael Jouvet. Later on, the drug was approved by the FDA for the treatment of narcolepsy. In the U.S., Provigil is also approved to cure other sleep-related disorders such as obstructive sleep apnea/hypopnea syndrome (OSAHS) and shift work sleep syndrome. Provigil is not to be taken by pregnant women and lactating moms, as well as those people who are allergic to Provigil. When taking Provigil, patients should inform the doctor if he has a history of taking other stimulants before and what were his body’s responses to the drugs. Provigil is not to be taken along with alcohol and drinks that may contain caffeine.

Nuvigil
Nuvigil hasn’t been released in the market but it is said to be very similar effects like Provigil. In 2007, Nuvigil was approved by the FDA to cure narcolepsy and excessive sleepiness (ES). Similar to generic Provigil Nuvigil should not be taken by persons who have heart problems, irregular heartbeat, and high blood pressure. This drug should not be taken by children as they are more sensitive to severe adverse side effects such as serious skin rash and other fatal ailment their bodies can’t tolerate.

Other complementary features of generic Provigil and Nuvigil
Provigil and Nuvigil have the same side effects for patients especially those who are not under a supervision of a doctor. These side effects range from mild to fatal conditions such as skin rash, mouth sore, headache, blindness, depression, agitation, hallucination, and palpitation and tremors, chest pain , and numbness of the skin.

Differences between generic Provigil and Nuvigil
 Provigil’s active ingredient is modafinil, a wakefulness-promoting agent that causes the patient to stay active while he under the influence of Provigil. It is assumed Provigil works by neurotransmitters inside the brain. Nuvigil’s active ingredient is armodafinil, which decreases of the patient’s extreme sleepiness. It is thought that armodafinil affects certain substances in the brain that is responsible in controlling sleep/wake cycle.

 Provigil is a racemic drug which means that composed of a mixture of two distinct versions of the same molecule, whereas, Nuvigil holds only one type of molecule.

 Nuvigil’s half-life is greater than Provigil, meaning Nuvigil stays on the blood for longer periods of time compared to Provigil.

Unconfirmed reports about Nuvigil and Provigil
It is said that Nuvigil will soon reach the market sometime after two years when Provigil will lose its patent. Sometime in 2011, Nuvigil will be the new Provigil only that it takes effect for longer periods of time than the latter.

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